TMTRx’s approach allows development of intranasal (IN) and intramuscular (IM) treatments 

Fentanyl and fentanyl analogues (FFAs), like all opioids, cause respiratory depression and also a phenomenon called wooden chest syndrome (WCS).

Based on a novel animal model developed by Dr. Torralva, TMTRx has demonstrated a unique mechanism that results in vocal cord closure (VCC) as a result of FFA overdose. 

Based on the unique mechanism of action that FFAs have and subsequent VCC, TMTRx is testing three classes of drugs, individually and in combination with naloxone, to determine their ability to reverse FFA overdose. All three classes have numerous generic drugs that are available for assessment of their ability to reverse FFA overdose. Based on extensive literature survey, TMT has identified several candidates. The combination formulations will be tested in the animal model specifically created to assess respiratory depression, chest wall rigidity, and vocal cord closure.